ClarigetAdult 250 mg bid, may be increased to 500 mg bid in more severe infections. Duration: 6-14 days. Patient w/ renal impairment (CrCl <30 mL/min) 250 mg once daily or 250 mg bid in more severe infections. Duration: 14 days. Mycobacterial infections 500 mg bid, may be increased to 1,000 mg bid. H. pylori 500 mg tid for 14 days. Childn 7.5 mg/kg bid. Max: 500 mg bid. Clariget ODAdult 500 mg once daily. Severe infections Max: 1000 mg (2 x 500 mg) once daily for 5-14 days.
Clariget Concomitant therapy w/ terfenadine in patients w/ preexisting cardiac abnormalities or electrolyte disturbances. Pregnancy & lactation. Clariget OD Hypersensitivity to macrolides antibiotics. Patients w/ CrCl <30 mL/min. Concomitant use w/ astemizole, pimozide, cisapride, terfenadine, ergotamine or dihydroergotamine, when in combination w/ ranitidine bismuth citrate on patients w/ a history of acute porphyria.
Theophylline, carbamazepine, terfenadine, digoxin, zidovudine, triazolam. Clariget Warfarin, ergot alkaloids, midazolam, cyclosporine, other macrolides. Clariget OD Astemizole, pimozide, cisapride, ergotamine or dihydroergotamine, when in combination w/ ranitidine bismuth citrate on patients w/ a history of acute porphyria; drugs metabolized by the CYP450, quinidine or disopyramide, HMG-CoA reductase inhibitors, oral anticoagulants, ritonavir, efavirenz, nevirapine, rifampicin, rifabutin, sildenafil, tadalafil, vardenafil, colchicine, itraconazole.
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